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So, these experiments involved aversive stimuli and rewarding stimuli and it tracked how different populations of dopaminergy neurons acted before the stimuli or cues.

But the dopamine systems aren't mediating any of the reward or noxious aversion. Instead they are the substrate for predicting it and wanting it. Not liking it. Dopaminergic systems aren't actually mediating reward.

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How does dopamine releasing drugs cause euphoria if dopaminergic systems aren't responsible for mediating reward?

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They increase the salience of naturally rewarding stimuli, mostly. Everything becomes seemingly more significant. But of course these dopaminergic neuronal populations in the VTA also project to other brain regions like the shell of the nucleus accumbens where they modulate, to a degree, the glutamergic neurons there that actually mediate reward.

The input from the VTA domainergic neurons is not required for nucleus accumbens expression of pleasure.

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But basically, it's your brain indicating that some really big reward is coming, that excitment, that's the "euphoria". But really dopaminergic drugs aren't great at real euphoria. Only anticipation and wanting of it and then making inconsequential rewards seem substantial.

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Thank you for the response, really interesting. It would be nice if we had some more content like that.

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Only anticipation and wanting of it and then making inconsequential rewards seem substantial.

You can know this in advance and still enjoy euphoria and seek substance simultaneously.

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But really dopaminergic drugs aren't great at real euphoria.

This isn't science, this is just story-telling. You can't measure my euphoria.

π